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Do not take the medication without first talking to your doctor if you are pregnant. <li>Cotrimoxazole passes into breast milk and may harm a nursing baby. Do not take it without first talking to your doctor if you are breast-feeding a baby. <li>Cotrimoxazole is not approved for use in children younger than 2 months of age. </ul> <b>How should I take sulfamethoxazole and trimethoprim? </b><ul> <li>Take this drug exactly as directed by your physician. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you. <li>Take each dose with a full glass of water. <li>Take it with food or milk if it upsets your stomach. <li>You may crush the tablets and put them in water or a soft food like applesauce or pudding if you cannot swallow them whole. <li>Take all of the Cotrimoxazole that has been prescribed for you even if you begin to feel better. 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